Traduction de «absence » (Français → Anglais) :

Congenital absence of breast with absent nipple

Death or serious disability (kernicterus) associated with failure to identify and treat hyperbilirubinemia in neonates

Definition: Either the prospect of sexual interaction produces sufficient fear or anxiety that sexual activity is avoided (sexual aversion) or sexual responses occur normally and orgasm is experienced but there is a lack of appropriate pleasure (lack of sexual enjoyment). | Anhedonia (sexual)

Definition: Parent talking to the child in a dismissive or insensitive way. Lack of interest in the child, of sympathy for the child's difficulties and of praise and encouragement. Irritated reaction to anxious behaviour and absence of sufficient physical comforting and emotional warmth.

Benign:myoclonic epilepsy in infancy | neonatal convulsions (familial) | Childhood absence epilepsy [pyknolepsy] Epilepsy with grand mal seizures on awakening Juvenile:absence epilepsy | myoclonic epilepsy [impulsive petit mal] | Nonspecific epileptic seizures:atonic | clonic | myoclonic | tonic | tonic-clonic

Definition: A group of disorders characterized by an early onset (usually in the first five years of life), lack of persistence in activities that require cognitive involvement, and a tendency to move from one activity to another without completing any one, together with disorganized, ill-regulated, and excessive activity. Several other abnormalities may be associated. Hyperkinetic children are often reckless and impulsive, prone to accidents, and find themselves in disciplinary trouble because of unthinking breaches of rules rather than deliberate defiance. Their relationships with adults are often socially disinhibited, with a lack of ...[+++]normal caution and reserve. They are unpopular with other children and may become isolated. Impairment of cognitive functions is common, and specific delays in motor and language development are disproportionately frequent. Secondary complications include dissocial behaviour and low self-esteem.

agammaglobulinaemia | immune deficiency

amenorrhoea | lack of periods

Dose increases from 400 mg to 600 mg or 800 mg in patients with chronic phase disease, or from 600 mg to a maximum of 800 mg (given as 400 mg twice daily) in patients with accelerated phase or blast crisis may be considered in the absence of severe adverse drug reaction and severe nonleukaemia-related neutropenia or thrombocytopenia in the following circumstances: disease progression (at any time); failure to achieve a satisfactory haematological response after at least 3 months of treatment; failure to achieve a cytogenetic response after 12 months of treatment; or loss of a previously achieved haematological and/or cytogenetic respo ...[+++]nse.

Haematological response criteria (all responses to be confirmed after 4 weeks): CHR: Study 0110 [WBC < 10 x 10 9 /l, platelets < 450 x 10 9 /l, myelocyte+metamyelocyte < 5% in blood, no blasts and promyelocytes in blood, basophils < 20%, no extramedullary involvement] and in studies 0102 and 0109 [ANC 1.5 x 10 9 /l, platelets 100 x 10 9 /l, no blood blasts, BM blasts < 5% and no extramedullary disease] NEL Same criteria as for CHR but ANC 1 x 10 9 /l and platelets 20 x 10 9 /l (0102 and 0109 only) RTC < 15% blasts BM and PB, < 30% blasts+promyelocytes in BM and PB, < 20% basophils in PB, no extramedullary disease other than spleen and liver (only for 0102 and 0109). BM = ...[+++] bone marrow, PB = peripheral blood

Patients showing a lack of response [lack of complete hematologic response (CHR) at six months, increasing white blood cell (WBC) counts or no major cytogenetic response (MCyR) at 24 months], loss of response (loss of CHR or MCyR) or severe intolerance to treatment were allowed to cross over to the alternate treatment arm.

Response was defined as: ≥ 50% reduction in the sum of angiomyolipoma volume relative to baseline, plus absence of new angiomyolipoma ≥ 1.0 cm in longest diameter, plus no increases in renal volume > 20% from nadir, plus absence of grade ≥ 2