Le principe de prudence devrait s'accompagner du recours au poids de la preuve comme l'ont préconisé la Commission mixte internationale et les rapports de Santé Canada tels que State of Knowledge Report on Environmental Contaminants and Human Health in the Great Lakes Basin, publié par Santé Canada en 1997.
A companion concept to the precautionary principle must be the weight-of-evidence approach, which has been advocated by the International Joint Commission and in Health Canada reports such as State of Knowledge Report on Environmental Contaminants and Human Health in the Great Lakes Basin, published by Health Canada in 1997.